The Very Rev Dr David Ison was among campaigners to claim the tests could “cut short” disabled people’s lives.
The letter also called on ministers to address the “shameful offences” of austerity measures.
The government said the assessments had been improved and could help disabled people get into employment.
The letter, titled The Downing Street Demand, called for an end to work capability assessments (WCA) which “demean and distress” disabled people.
It stated that government policies forced some of the most deprived members of society to “shoulder the heaviest burden of national debt created by the super-rich”.
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